Fabian Theis
Principal investigator
Single-cell genomics · Perturbation responses · Bulk omics and genetics
Topics · Biology and medicine · Disease areas
Brain and mental health
Work on the nervous system, such as neurons and the brain and their development, and on neurological and psychiatric disorders. Not for neural networks in machine learning.
In Biology and medicine › Disease areas76 works1 person1 tool
People1
Publications76
Integrated manufacturing platform for cortical organoids reveals early phosphatase and prefoldin dysregulation in MAPT V337M neurons
Multimodal discovery of a pathogenic B-cell-dependent T-cell state in multiple sclerosis
Plasticity of human microglia and brain perivascular macrophages in aging and Alzheimer’s disease
Transcriptional repression by TGIF2 coordinates neurogenic priming and neural stem cell maintenance
InterScale reveals multi-scale cellular interaction programs in spatial transcriptomics
TNF alpha unmasks enteric malate aspartate shuttle dysfunction bridging Parkinson disease and intestinal inflammation
Large-scale proteomics across neurological disorders uncovers biomarker panel and targets in multiple sclerosis
Single-cell atlas of the transcriptome and chromatin accessibility in the human retina
Single-cell characterization of the adult male hippocampus suggests a prominent, and cell-type specific, role for Nrgn and Sgk1 in response to a social stressor
Brain Region-Specific Oligodendrocyte States Highlight Mitochondrial Gene Upregulation and Loss of Canonical Identity Signatures in Alzheimer’s Disease
A foundation model to predict and capture human cognition
Charting the single-cell and spatial landscape of IDH-wild-type glioblastoma with GBmap
GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice
Exon-variant interplay and multi-modal evidence identify endocrine dysregulation in severe psychiatric disorders impacting excitatory neurons
Stress in the ventral hippocampus under single-cell resolution
TGIF2 is a major regulator of neural stem cell fate and neurogenic priming
Chronic exposure to glucocorticoids amplifies inhibitory neuron cell fate during human neurodevelopment in organoids
ProCyon: A multimodal foundation model for protein phenotypes
Multiplexing cortical brain organoids for the longitudinal dissection of developmental traits at single-cell resolution
Opportunities and challenges of single-cell and spatially resolved genomics methods for neuroscience discovery
An integrated transcriptomic cell atlas of human neural organoids
Shared inflammatory glial cell signature after stab wound injury, revealed by spatial, temporal, and cell-type-specific profiling of the murine cerebral cortex
Community effort to unravel the complex human neuronal landscape exemplified for the striatum
Early life adversity shapes social subordination and cell type–specific transcriptomic patterning in the ventral hippocampus
A reversible state of hypometabolism in a human cellular model of sporadic Parkinson’s disease
Distinct molecular profiles of skull bone marrow in health and neurological disorders
T cells modulate the microglial response to brain ischemia
Spatial proteomics in three-dimensional intact specimens
TDP-43 condensates and lipid droplets regulate the reactivity of microglia and regeneration after traumatic brain injury
Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease
Variant-risk-exon interplay impacts circadian rhythm and dopamine signaling pathway in severe psychiatric disorders
Interpretable surface-based detection of focal cortical dysplasias: a Multi-centre Epilepsy Lesion Detection study
Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2
Cell-Type-Specific Impact of Glucocorticoid Receptor Activation on the Developing Brain: A Cerebral Organoid Study
Parkinson's disease motor symptoms rescue by CRISPRa‐reprogramming astrocytes into GABAergic neurons
Concept of the Munich/Augsburg Consortium Precision in Mental Health for the German Center of Mental Health
Multi-omics and 3D-imaging reveal bone heterogeneity and unique calvaria cells in neuroinflammation
Cellular connectomes as arbiters of local circuit models in the cerebral cortex
Single-cell molecular profiling of all three components of the HPA axis reveals adrenal ABCB1 as a regulator of stress adaptation
Epithelial Planar Bipolarity Emerges from Notch-Mediated Asymmetric Inhibition of Emx2
Cell-type specific impact of glucocorticoid receptor activation on the developing brain
S.11.01 Brain organoids as models of the developing human brain: deciphering the molecular signature of prenatal stress
POLYGENIC BURDEN ANALYSIS OF LONGITUDINAL CLUSTERS OF PSYCHOPATHOLOGICAL FEATURES IN A CROSS-DIAGNOSTIC GROUP OF INDIVIDUALS WITH SEVERE MENTAL ILLNESS
F96POLYGENIC RISK SCORE ANALYSIS OF TRAJECTORIES OF COGNITIVE PERFORMANCE IN PSYCHIATRIC PATIENTS
SA125POLYGENIC BURDEN ANALYSIS OF LONGITUDINAL CLUSTERS OF PSYCHOPATHOLOGICAL FEATURES IN A CROSS-DIAGNOSTIC GROUP OF INDIVIDUALS WITH SEVERE MENTAL ILLNESS
Increasing Neural Stem Cell Division Asymmetry and Quiescence Are Predicted to Contribute to the Age-Related Decline in Neurogenesis
Impact of Brain Fatty Acid Signaling on Peripheral Insulin Action in Mice
Calcium-regulatory proteins as modulators of chemotherapy in human neuroblastoma
Polygenic Burden Analysis of Longitudinal Clusters of Psychopathological Features In A Cross-Diagnostic Group of Individuals with Severe Mental Illness
Integrating Polygenic Allele Burden Information And Phenomic Data To Characterize Complex Disease Trajectories In Severe Mental Illness
POLYGENIC BURDEN ANALYSIS OF LONGITUDINAL CLUSTERS OF QUALITY OF LIFE AND FUNCTIONING IN PATIENTS WITH SEVERE MENTAL ILLNESS
The Role Of Micrornas In The Course Of Severe Mental Disorders
MicroRNA-138 promotes acquired alkylator resistance in glioblastoma by targeting the Bcl-2-interacting mediator BIM
Transcriptional Mechanisms of Proneural Factors and REST in Regulating Neuronal Reprogramming of Astrocytes
Live imaging of adult neural stem cell behavior in the intact and injured zebrafish brain
A Critical Period for Postnatal Adaptive Plasticity in a Model of Motor Axon Miswiring
Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone
Mouse IDGenes: a reference database for genetic interactions in the developing mouse brain
Hypothalamic miR-103 Protects from Hyperphagic Obesity in Mice
ODE Constrained Mixture Modelling: A Method for Unraveling Subpopulation Structures and Dynamics
Wound-healing growth factor, basic FGF, induces Erk1/2-dependent mechanical hyperalgesia
Metabolomic profiles in individuals with negative affectivity and social inhibition: A population-based study of Type D personality
Sharpening of expression domains induced by transcription and microRNA regulationwithin a spatio-temporal model of mid-hindbrain boundary formation
Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation
A Unilateral Negative Feedback Loop Between miR-200 microRNAs and Sox2/E2F3 Controls Neural Progenitor Cell-Cycle Exit and Differentiation
Essstörungen im Internet: Eine experimentelle Studie zu den Auswirkungen von Pro-Essstörungs- und Selbsthilfewebsites
MicroRNA Loss Enhances Learning and Memory in Mice
Spatial Analysis of Expression Patterns Predicts Genetic Interactions at the Mid-Hindbrain Boundary
Zebrafish reward mutants reveal novel transcripts mediating the behavioral effects of amphetamine
Erythropoietin enhances hippocampal long-term potentiation and memory
Episode-Specific Differential Gene Expression of Peripheral Blood Mononuclear Cells in Rapid Cycling Supports Novel Treatment Approaches
Phase-specific differential gene expression of peripheral blood mononuclear cells in rapid cycling syndrome
A Toolbox for Model-Free Analysis of fMRI Data
3D Spatial Analysis of fMRI Data on a Word Perception Task
Spatial ICA of fMRI data in time windows
3D spatial analysis of fMRI data: a comparison of ICA and GLM analysis on a word perception task
Software1
spatial_atlas_ssl
Self-supervised learning for mask inpainting on large spatial atlasses such as the BICCN 2.0 data.
5Jupyter Notebook