Plate IV.406 · Publications
Lifetime study in mice after acute low-dose ionizing radiation: a multifactorial study with special focus on cataract risk
Article in Radiation and Environmental Biophysics, 11 January 2018.
Abstract
Because of the increasing application of ionizing radiation in medicine, quantitative data on effects of low-dose radiation are needed to optimize radiation protection, particularly with respect to cataract development. Using mice as mammalian animal model, we applied a single dose of 0, 0.063, 0.125 and 0.5 Gy at 10 weeks of age, determined lens opacities for up to 2 years and compared it with overall survival, cytogenetic alterations and cancer development. The highest dose was significantly associated with increased body weight and reduced survival rate. Chromosomal aberrations in bone marrow cells showed a dose-dependent increase 12 months after irradiation. Pathological screening indicated a dose-dependent risk for several types of tumors. Scheimpflug imaging of the lens revealed a significant dose-dependent effect of 1% of lens opacity. Comparison of different biological end points demonstrated long-term effects of low-dose irradiation for several biological end points.
Cite
@article{dalke2018lifetime,
title = {{Lifetime study in mice after acute low-dose ionizing radiation: a multifactorial study with special focus on cataract risk}},
author = {Dalke, Claudia and Neff, Frauke and Bains, Savneet Kaur and Bright, Scott and Lord, Deborah and Reitmeir, Peter and Rößler, Ute and Samaga, Daniel and Unger, Kristian and Braselmann, Herbert and Wagner, Florian and Greiter, Matthias and Gomolka, Maria and Hornhardt, Sabine and Kunze, Sarah and Kempf, Stefan J. and Garrett, Lillian and Hölter, Sabine M. and Wurst, Wolfgang and Rosemann, Michael and Azimzadeh, Omid and Tapio, Soile and Aubele, Michaela and Theis, Fabian and Hoeschen, Christoph and Slijepcevic, Predrag and Kadhim, Munira and Atkinson, Michael and Zitzelsberger, Horst and Kulka, Ulrike and Graw, Jochen},
journal = {Radiation and Environmental Biophysics},
publisher = {Springer Science and Business Media LLC},
year = {2018},
month = jan,
doi = {10.1007/s00411-017-0728-z},
url = {https://doi.org/10.1007/s00411-017-0728-z},
pmid = {29327260},
pmcid = {PMC5902533}
}