Plate IV.128 · Publications

Vitessce: integrative visualization of multimodal and spatially resolved single-cell data

Article in Nature Methods, 27 September 2024.

Open accessResearch area: Spatial, Omics Data

Authors

  1. Mark S. Keller
  2. Ilan Gold
  3. Chuck McCallum
  4. Trevor Manz
  5. Peter V. Kharchenko
  6. Nils Gehlenborg

Abstract

Multiomics technologies with single-cell and spatial resolution make it possible to measure thousands of features across millions of cells. However, visual analysis of high-dimensional transcriptomic, proteomic, genome-mapped and imaging data types simultaneously remains a challenge. Here we describe Vitessce, an interactive web-based visualization framework for exploration of multimodal and spatially resolved single-cell data. We demonstrate integrative visualization of millions of data points, including cell-type annotations, gene expression quantities, spatially resolved transcripts and cell segmentations, across multiple coordinated views. The open-source software is available at http://vitessce.io.

Cite

@article{keller2024vitessce,
  title = {{Vitessce: integrative visualization of multimodal and spatially resolved single-cell data}},
  author = {Keller, Mark S. and Gold, Ilan and McCallum, Chuck and Manz, Trevor and Kharchenko, Peter V. and Gehlenborg, Nils},
  journal = {Nature Methods},
  publisher = {Springer Science and Business Media LLC},
  year = {2024},
  month = sep,
  doi = {10.1038/s41592-024-02436-x},
  url = {https://doi.org/10.1038/s41592-024-02436-x},
  pmid = {39333268},
  pmcid = {PMC11725496}
}
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