Plate IV.233 · Publications
Alveolar macrophages in early stage COPD show functional deviations with properties of impaired immune activation
Article in Frontiers in Immunology, 28 July 2022.
Abstract
Despite its high prevalence, the cellular and molecular mechanisms of chronic obstructive pulmonary disease (COPD) are far from being understood. Here, we determine disease-related changes in cellular and molecular compositions within the alveolar space and peripheral blood of a cohort of COPD patients and controls. Myeloid cells were the largest cellular compartment in the alveolar space with invading monocytes and proliferating macrophages elevated in COPD. Modeling cell-to-cell communication, signaling pathway usage, and transcription factor binding predicts TGF-β1 to be a major upstream regulator of transcriptional changes in alveolar macrophages of COPD patients. Functionally, macrophages in COPD showed reduced antigen presentation capacity, accumulation of cholesteryl ester, reduced cellular chemotaxis, and mitochondrial dysfunction, reminiscent of impaired immune activation.
Cite
@article{bassler2022alveolar,
title = {{Alveolar macrophages in early stage COPD show functional deviations with properties of impaired immune activation}},
author = {Baßler, Kevin and Fujii, Wataru and Kapellos, Theodore S. and Dudkin, Erika and Reusch, Nico and Horne, Ari and Reiz, Benedikt and Luecken, Malte D. and Osei-Sarpong, Collins and Warnat-Herresthal, Stefanie and Bonaguro, Lorenzo and Schulte-Schrepping, Jonas and Wagner, Allon and Günther, Patrick and Pizarro, Carmen and Schreiber, Tina and Knoll, Rainer and Holsten, Lisa and Kröger, Charlotte and De Domenico, Elena and Becker, Matthias and Händler, Kristian and Wohnhaas, Christian T. and Baumgartner, Florian and Köhler, Meike and Theis, Heidi and Kraut, Michael and Wadsworth, Marc H. and Hughes, Travis K. and Ferreira, Humberto J. and Hinkley, Emily and Kaltheuner, Ines H. and Geyer, Matthias and Thiele, Christoph and Shalek, Alex K. and Feißt, Andreas and Thomas, Daniel and Dickten, Henning and Beyer, Marc and Baum, Patrick and Yosef, Nir and Aschenbrenner, Anna C. and Ulas, Thomas and Hasenauer, Jan and Theis, Fabian J. and Skowasch, Dirk and Schultze, Joachim L.},
journal = {Frontiers in Immunology},
publisher = {Frontiers Media SA},
year = {2022},
month = jul,
doi = {10.3389/fimmu.2022.917232},
url = {https://doi.org/10.3389/fimmu.2022.917232},
pmid = {35979364},
pmcid = {PMC9377018}
}