Plate IV.405 · Publications
Maternal whole blood cell miRNA-340 is elevated in gestational diabetes and inversely regulated by glucose and insulin
Article in Scientific Reports, 22 January 2018.
Abstract
The number of pregnancies complicated by gestational diabetes (GDM) is increasing worldwide. To identify novel characteristics of GDM, we studied miRNA profiles of maternal and fetal whole blood cells (WBCs) from GDM and normal glucose tolerant (NGT) pregnant women matched for body mass index and maternal age. After adjustment for maternal weight gain and pregnancy week, we identified 29 mature micro-RNAs (miRNAs) up-regulated in GDM, one of which, i.e., miRNA-340, was validated by qPCR. mRNA and protein expression of PAIP1, a miRNA-340 target gene, was found down-regulated in GDM women, accordingly. In lymphocytes derived from the mothers' blood and treated in vitro, insulin increased and glucose reduced miRNA-340 expression. In fetal cord blood samples, no associations of miRNA-340 with maternal GDM were observed. Our results provide evidence for insulin-induced epigenetic, i.e., miRNA-dependent, programming of maternal WBCs in GDM.
Versions2
- CorrectionScientific Reports10.1038/s41598-022-11273-x
- PublishedScientific Reports10.1038/s41598-018-19200-9
Cite
@article{stirm2018maternal,
title = {{Maternal whole blood cell miRNA-340 is elevated in gestational diabetes and inversely regulated by glucose and insulin}},
author = {Stirm, Laura and Huypens, Peter and Sass, Steffen and Batra, Richa and Fritsche, Louise and Brucker, Sara and Abele, Harald and Hennige, Anita M. and Theis, Fabian and Beckers, Johannes and Hrabě de Angelis, Martin and Fritsche, Andreas and Häring, Hans-Ulrich and Staiger, Harald},
journal = {Scientific Reports},
publisher = {Springer Science and Business Media LLC},
year = {2018},
month = jan,
doi = {10.1038/s41598-018-19200-9},
url = {https://doi.org/10.1038/s41598-018-19200-9},
pmid = {29358694},
pmcid = {PMC5778051}
}