Plate IV.196 · Publications
Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease
Article in Cell Reports, June 2023.
Abstract
Systemic inflammation is established as part of late-stage severe lung disease, but molecular, functional, and phenotypic changes in peripheral immune cells in early disease stages remain ill defined. Chronic obstructive pulmonary disease (COPD) is a major respiratory disease characterized by small-airway inflammation, emphysema, and severe breathing difficulties. Using single-cell analyses we demonstrate that blood neutrophils are already increased in early-stage COPD, and changes in molecular and functional neutrophil states correlate with lung function decline. Assessing neutrophils and their bone marrow precursors in a murine cigarette smoke exposure model identified similar molecular changes in blood neutrophils and precursor populations that also occur in the blood and lung. Our study shows that systemic molecular alterations in neutrophils and their precursors are part of early-stage COPD, a finding to be further explored for potential therapeutic targets and biomarkers for early diagnosis and patient stratification.
Cite
@article{kapellos2023systemic,
title = {{Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease}},
author = {Kapellos, Theodore S. and Baßler, Kevin and Fujii, Wataru and Nalkurthi, Christina and Schaar, Anna C. and Bonaguro, Lorenzo and Pecht, Tal and Galvao, Izabela and Agrawal, Shobhit and Saglam, Adem and Dudkin, Erica and Frishberg, Amit and de Domenico, Elena and Horne, Arik and Donovan, Chantal and Kim, Richard Y. and Gallego-Ortega, David and Gillett, Tessa E. and Ansari, Meshal and Schulte-Schrepping, Jonas and Offermann, Nina and Antignano, Ignazio and Sivri, Burcu and Lu, Wenying and Eapen, Mathew S. and van Uelft, Martina and Osei-Sarpong, Collins and van den Berge, Maarten and Donker, Hylke C. and Groen, Harry J.M. and Sohal, Sukhwinder S. and Klein, Johanna and Schreiber, Tina and Feißt, Andreas and Yildirim, Ali Önder and Schiller, Herbert B. and Nawijn, Martijn C. and Becker, Matthias and Händler, Kristian and Beyer, Marc and Capasso, Melania and Ulas, Thomas and Hasenauer, Jan and Pizarro, Carmen and Theis, Fabian J. and Hansbro, Philip M. and Skowasch, Dirk and Schultze, Joachim L.},
journal = {Cell Reports},
publisher = {Elsevier BV},
year = {2023},
month = jun,
doi = {10.1016/j.celrep.2023.112525},
url = {https://doi.org/10.1016/j.celrep.2023.112525},
pmid = {37243592},
pmcid = {PMC10320832}
}