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Plate IV.403 · Publications

Whither systems medicine?

Review in Experimental & Molecular Medicine, March 2018.

ReviewOpen accessImages, Deep Learning

  1. Rolf Apweiler
  2. Tim Beissbarth
  3. Michael R Berthold
  4. Nils Blüthgen
  5. Yvonne Burmeister
  6. Olaf Dammann
  7. Andreas Deutsch
  8. Friedrich Feuerhake
  9. Andre Franke
  10. Jan Hasenauer
  11. Steve Hoffmann
  12. Thomas Höfer
  13. Peter LM Jansen
  14. Lars Kaderali
  15. Ursula Klingmüller
  16. Ina Koch
  17. Oliver Kohlbacher
  18. Lars Kuepfer
  19. Frank Lammert
  20. Dieter Maier
  21. Nico Pfeifer
  22. Nicole Radde
  23. Markus Rehm
  24. Ingo Roeder
  25. Julio Saez-Rodriguez
  26. Ulrich Sax
  27. Bernd Schmeck
  28. Andreas Schuppert
  29. Bernd Seilheimer
  30. Fabian J Theis
  31. Julio Vera
  32. Olaf Wolkenhauer

Abstract

New technologies to generate, store and retrieve medical and research data are inducing a rapid change in clinical and translational research and health care. Systems medicine is the interdisciplinary approach wherein physicians and clinical investigators team up with experts from biology, biostatistics, informatics, mathematics and computational modeling to develop methods to use new and stored data to the benefit of the patient. We here provide a critical assessment of the opportunities and challenges arising out of systems approaches in medicine and from this provide a definition of what systems medicine entails. Based on our analysis of current developments in medicine and healthcare and associated research needs, we emphasize the role of systems medicine as a multilevel and multidisciplinary methodological framework for informed data acquisition and interdisciplinary data analysis to extract previously inaccessible knowledge for the benefit of patients.

Cite

@article{apweiler2018whither,
  title = {{Whither systems medicine?}},
  author = {Apweiler, Rolf and Beissbarth, Tim and Berthold, Michael R and Blüthgen, Nils and Burmeister, Yvonne and Dammann, Olaf and Deutsch, Andreas and Feuerhake, Friedrich and Franke, Andre and Hasenauer, Jan and Hoffmann, Steve and Höfer, Thomas and Jansen, Peter LM and Kaderali, Lars and Klingmüller, Ursula and Koch, Ina and Kohlbacher, Oliver and Kuepfer, Lars and Lammert, Frank and Maier, Dieter and Pfeifer, Nico and Radde, Nicole and Rehm, Markus and Roeder, Ingo and Saez-Rodriguez, Julio and Sax, Ulrich and Schmeck, Bernd and Schuppert, Andreas and Seilheimer, Bernd and Theis, Fabian J and Vera, Julio and Wolkenhauer, Olaf},
  journal = {Experimental \& Molecular Medicine},
  publisher = {Springer Science and Business Media LLC},
  year = {2018},
  month = mar,
  doi = {10.1038/emm.2017.290},
  url = {https://doi.org/10.1038/emm.2017.290},
  pmid = {29497170},
  pmcid = {PMC5898894}
}
.bib file