Plate IV.512 · Publications
Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone
Article in Nature Neuroscience, 2 March 2015.
Abstract
We analyzed the progeny of individual neural stem cells (NSCs) of the mouse adult subependymal zone (SEZ) in vivo and found a markedly fast lineage amplification, as well as limited NSC self-renewal and exhaustion in a few weeks. We further unraveled the mechanisms of neuronal subtype generation, finding that a higher proportion of NSCs were dedicated to generate deep granule cells in the olfactory bulb and that larger clones were produced by these NSCs.
Cite
@article{calzolari2015fast,
title = {{Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone}},
author = {Calzolari, Filippo and Michel, Julia and Baumgart, Emily Violette and Theis, Fabian and Götz, Magdalena and Ninkovic, Jovica},
journal = {Nature Neuroscience},
publisher = {Springer Science and Business Media LLC},
year = {2015},
month = mar,
doi = {10.1038/nn.3963},
url = {https://doi.org/10.1038/nn.3963},
pmid = {25730673}
}