Plate IV.310 · Publications
LifeTime and improving European healthcare through cell-based interceptive medicine
Review in Nature, 7 September 2020.
Abstract
Here we describe the LifeTime Initiative, which aims to track, understand and target human cells during the onset and progression of complex diseases, and to analyse their response to therapy at single-cell resolution. This mission will be implemented through the development, integration and application of single-cell multi-omics and imaging, artificial intelligence and patient-derived experimental disease models during the progression from health to disease. The analysis of large molecular and clinical datasets will identify molecular mechanisms, create predictive computational models of disease progression, and reveal new drug targets and therapies. The timely detection and interception of disease embedded in an ethical and patient-centred vision will be achieved through interactions across academia, hospitals, patient associations, health data management systems and industry. The application of this strategy to key medical challenges in cancer, neurological and neuropsychiatric disorders, and infectious, chronic inflammatory and cardiovascular diseases at the single-cell level will usher in cell-based interceptive medicine in Europe over the next decade.
Versions2
- CorrectionNature10.1038/s41586-021-03287-8
- PublishedNature10.1038/s41586-020-2715-9
Cite
@article{rajewsky2020lifetime,
title = {{LifeTime and improving European healthcare through cell-based interceptive medicine}},
author = {Rajewsky, Nikolaus and Almouzni, Geneviève and Gorski, Stanislaw A. and Aerts, Stein and Amit, Ido and Bertero, Michela G. and Bock, Christoph and Bredenoord, Annelien L. and Cavalli, Giacomo and Chiocca, Susanna and Clevers, Hans and De Strooper, Bart and Eggert, Angelika and Ellenberg, Jan and Fernández, Xosé M. and Figlerowicz, Marek and Gasser, Susan M. and Hubner, Norbert and Kjems, Jørgen and Knoblich, Jürgen A. and Krabbe, Grietje and Lichter, Peter and Linnarsson, Sten and Marine, Jean-Christophe and Marioni, John C. and Marti-Renom, Marc A. and Netea, Mihai G. and Nickel, Dörthe and Nollmann, Marcelo and Novak, Halina R. and Parkinson, Helen and Piccolo, Stefano and Pinheiro, Inês and Pombo, Ana and Popp, Christian and Reik, Wolf and Roman-Roman, Sergio and Rosenstiel, Philip and Schultze, Joachim L. and Stegle, Oliver and Tanay, Amos and Testa, Giuseppe and Thanos, Dimitris and Theis, Fabian J. and Torres-Padilla, Maria-Elena and Valencia, Alfonso and Vallot, Céline and van Oudenaarden, Alexander and Vidal, Marie and Voet, Thierry and LifeTime Community Working Groups and Alberi, Lavinia and Alexander, Stephanie and Alexandrov, Theodore and Arenas, Ernest and Bagni, Claudia and Balderas, Robert and Bandelli, Andrea and Becher, Burkhard and Becker, Matthias and Beerenwinkel, Niko and Benkirame, Monsef and Beyer, Marc and Bickmore, Wendy and Biessen, Erik E. A. L. and Blomberg, Niklas and Blumcke, Ingmar and Bodenmiller, Bernd and Borroni, Barbara and Boumpas, Dimitrios T. and Bourgeron, Thomas and Bowers, Sarion and Braeken, Dries and Brooksbank, Catherine and Brose, Nils and Bruining, Hilgo and Bury, Jo and Caporale, Nicolo and Cattoretti, Giorgio and Chabane, Nadia and Chneiweiss, Hervé and Cook, Stuart A. and Curatolo, Paolo and de Jonge, Marien I. and Deplancke, Bart and De Strooper, Bart and de Witte, Peter and Dimmeler, Stefanie and Draganski, Bogdan and Drews, Anna and Dumbrava, Costica and Engelhardt, Stefan and Gasser, Thomas and Giamarellos-Bourboulis, Evangelos J. and Graff, Caroline and Grün, Dominic and Gut, Ivo and Hansson, Oskar and Henshall, David C. and Herland, Anna and Heutink, Peter and Heymans, Stephane R. B. and Heyn, Holger and Huch, Meritxell and Huitinga, Inge and Jackowiak, Paulina and Jongsma, Karin R. and Journot, Laurent and Junker, Jan Philipp and Katz, Shauna and Kehren, Jeanne and Kempa, Stefan and Kirchhof, Paulus and Klein, Christine and Koralewska, Natalia and Korbel, Jan O. and Kühnemund, Malte and Lamond, Angus I. and Lauwers, Elsa and Le Ber, Isabelle and Leinonen, Ville and Tobon, Alejandro Lopez and Lundberg, Emma and Lunkes, Astrid and Maatz, Henrike and Mann, Matthias and Marelli, Luca and Matser, Vera and Matthews, Paul M. and Mechta-Grigoriou, Fatima and Menon, Radhika and Nielsen, Anne F. and Pagani, Massimiliano and Pasterkamp, R. Jeroen and Pitkänen, Asla and Popescu, Valentin and Pottier, Cyril and Puisieux, Alain and Rademakers, Rosa and Reiling, Dory and Reiner, Orly and Remondini, Daniel and Ritchie, Craig and Rohrer, Jonathan D. and Saliba, Antoine-Emmanuel and Sanchez-Valle, Raquel and Santosuosso, Amedeo and Sauter, Arnold and Scheltema, Richard A. and Scheltens, Philip and Schiller, Herbert B. and Schneider, Anja and Seibler, Philip and Sheehan-Rooney, Kelly and Shields, David and Sleegers, Kristel and Smit, August B. and Smith, Kenneth G. C. and Smolders, Ilse and Synofzik, Matthis and Tam, Wai Long and Teichmann, Sarah and Thom, Maria and Turco, Margherita Y. and van Beusekom, Heleen M. M. and Vandenberghe, Rik and Van den Hoecke, Silvie and Van de Poel, Ibo and van der Ven, Andre and van der Zee, Julie and van Lunzen, Jan and van Minnebruggen, Geert and van Oudenaarden, Alexander and Van Paesschen, Wim and van Swieten, John and van Vught, Remko and Verhage, Matthijs and Verstreken, Patrik and Villa, Carlo Emanuele and Vogel, Jörg and von Kalle, Christof and Walter, Jörn and Weckhuysen, Sarah and Weichert, Wilko and Wood, Louisa and Ziegler, Anette-Gabriele and Zipp, Frauke},
journal = {Nature},
publisher = {Springer Science and Business Media LLC},
year = {2020},
month = sep,
doi = {10.1038/s41586-020-2715-9},
url = {https://doi.org/10.1038/s41586-020-2715-9},
pmid = {32894860},
pmcid = {PMC7656507}
}