Plate IV.408 · Publications
The Human Cell Atlas
Article in eLife, 5 December 2017.
Abstract
The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe to complete the 150-year-old effort to identify all cell types in the human body. The Human Cell Atlas Project is an international collaborative effort that aims to define all human cell types in terms of distinctive molecular profiles (such as gene expression profiles) and to connect this information with classical cellular descriptions (such as location and morphology). An open comprehensive reference map of the molecular state of cells in healthy human tissues would propel the systematic study of physiological states, developmental trajectories, regulatory circuitry and interactions of cells, and also provide a framework for understanding cellular dysregulation in human disease. Here we describe the idea, its potential utility, early proofs-of-concept, and some design considerations for the Human Cell Atlas, including a commitment to open data, code, and community.
Versions2
- PublishedeLife10.7554/elife.27041
- PreprintbioRxiv10.1101/121202
Cite
@article{regev2017human,
title = {{The Human Cell Atlas}},
author = {Regev, Aviv and Teichmann, Sarah A and Lander, Eric S and Amit, Ido and Benoist, Christophe and Birney, Ewan and Bodenmiller, Bernd and Campbell, Peter and Carninci, Piero and Clatworthy, Menna and Clevers, Hans and Deplancke, Bart and Dunham, Ian and Eberwine, James and Eils, Roland and Enard, Wolfgang and Farmer, Andrew and Fugger, Lars and Göttgens, Berthold and Hacohen, Nir and Haniffa, Muzlifah and Hemberg, Martin and Kim, Seung and Klenerman, Paul and Kriegstein, Arnold and Lein, Ed and Linnarsson, Sten and Lundberg, Emma and Lundeberg, Joakim and Majumder, Partha and Marioni, John C and Merad, Miriam and Mhlanga, Musa and Nawijn, Martijn and Netea, Mihai and Nolan, Garry and Pe'er, Dana and Phillipakis, Anthony and Ponting, Chris P and Quake, Stephen and Reik, Wolf and Rozenblatt-Rosen, Orit and Sanes, Joshua and Satija, Rahul and Schumacher, Ton N and Shalek, Alex and Shapiro, Ehud and Sharma, Padmanee and Shin, Jay W and Stegle, Oliver and Stratton, Michael and Stubbington, Michael J T and Theis, Fabian J and Uhlen, Matthias and van Oudenaarden, Alexander and Wagner, Allon and Watt, Fiona and Weissman, Jonathan and Wold, Barbara and Xavier, Ramnik and Yosef, Nir and Human Cell Atlas Meeting Participants},
journal = {eLife},
publisher = {eLife Sciences Publications, Ltd},
year = {2017},
month = dec,
doi = {10.7554/elife.27041},
url = {https://doi.org/10.7554/elife.27041},
pmid = {29206104},
pmcid = {PMC5762154}
}