Plate IV.183 · Publications
Distinct molecular profiles of skull bone marrow in health and neurological disorders
Article in Cell, August 2023.
Abstract
The bone marrow in the skull is important for shaping immune responses in the brain and meninges, but its molecular makeup among bones and relevance in human diseases remain unclear. Here, we show that the mouse skull has the most distinct transcriptomic profile compared with other bones in states of health and injury, characterized by a late-stage neutrophil phenotype. In humans, proteome analysis reveals that the skull marrow is the most distinct, with differentially expressed neutrophil-related pathways and a unique synaptic protein signature. 3D imaging demonstrates the structural and cellular details of human skull-meninges connections (SMCs) compared with veins. Last, using translocator protein positron emission tomography (TSPO-PET) imaging, we show that the skull bone marrow reflects inflammatory brain responses with a disease-specific spatial distribution in patients with various neurological disorders. The unique molecular profile and anatomical and functional connections of the skull show its potential as a site for diagnosing, monitoring, and treating brain diseases.
Cite
@article{kolabas2023distinct,
title = {{Distinct molecular profiles of skull bone marrow in health and neurological disorders}},
author = {Kolabas, Zeynep Ilgin and Kuemmerle, Louis B. and Perneczky, Robert and Förstera, Benjamin and Ulukaya, Selin and Ali, Mayar and Kapoor, Saketh and Bartos, Laura M. and Büttner, Maren and Caliskan, Ozum Sehnaz and Rong, Zhouyi and Mai, Hongcheng and Höher, Luciano and Jeridi, Denise and Molbay, Muge and Khalin, Igor and Deligiannis, Ioannis K. and Negwer, Moritz and Roberts, Kenny and Simats, Alba and Carofiglio, Olga and Todorov, Mihail I. and Horvath, Izabela and Ozturk, Furkan and Hummel, Selina and Biechele, Gloria and Zatcepin, Artem and Unterrainer, Marcus and Gnörich, Johannes and Roodselaar, Jay and Shrouder, Joshua and Khosravani, Pardis and Tast, Benjamin and Richter, Lisa and Díaz-Marugán, Laura and Kaltenecker, Doris and Lux, Laurin and Chen, Ying and Zhao, Shan and Rauchmann, Boris-Stephan and Sterr, Michael and Kunze, Ines and Stanic, Karen and Kan, Vanessa W.Y. and Besson-Girard, Simon and Katzdobler, Sabrina and Palleis, Carla and Schädler, Julia and Paetzold, Johannes C. and Liebscher, Sabine and Hauser, Anja E. and Gokce, Ozgun and Lickert, Heiko and Steinke, Hanno and Benakis, Corinne and Braun, Christian and Martinez-Jimenez, Celia P. and Buerger, Katharina and Albert, Nathalie L. and Höglinger, Günter and Levin, Johannes and Haass, Christian and Kopczak, Anna and Dichgans, Martin and Havla, Joachim and Kümpfel, Tania and Kerschensteiner, Martin and Schifferer, Martina and Simons, Mikael and Liesz, Arthur and Krahmer, Natalie and Bayraktar, Omer A. and Franzmeier, Nicolai and Plesnila, Nikolaus and Erener, Suheda and Puelles, Victor G. and Delbridge, Claire and Bhatia, Harsharan Singh and Hellal, Farida and Elsner, Markus and Bechmann, Ingo and Ondruschka, Benjamin and Brendel, Matthias and Theis, Fabian J. and Erturk, Ali},
journal = {Cell},
publisher = {Elsevier BV},
year = {2023},
month = aug,
doi = {10.1016/j.cell.2023.07.009},
url = {https://doi.org/10.1016/j.cell.2023.07.009},
pmid = {37562402},
pmcid = {PMC10443631}
}