Plate IV.289 · Publications

Comparison of genome-wide gene expression profiling by RNA Sequencing versus microarray in bronchial biopsies of COPD patients before and after inhaled corticosteroid treatment: does it provide new insights?

Article in ERJ Open Research, April 2021.

Open accessResearch area: Single Cell RNA, Gene Expression

Authors

  1. Benedikt Ditz
  2. Jeunard G. Boekhoudt
  3. Hananeh Aliee
  4. Fabian J. Theis
  5. Martijn Nawijn
  6. Corry-Anke Brandsma
  7. Pieter S. Hiemstra
  8. Wim Timens
  9. Gaik W. Tew
  10. Michele A. Grimbaldeston
  11. Margaret Neighbors
  12. Victor Guryev
  13. Maarten van den Berge
  14. Alen Faiz

Abstract

More DEGs are detected by RNA-Seq than microarrays in COPD lung biopsies and are associated with immunological pathways. Performing bulk tissue cell-type deconvolution in microarray lung samples, using the SVR method, reflects RNA-Seq results. https://bit.ly/2N8sY3s.

Cite

@article{ditz2021comparison,
  title = {{Comparison of genome-wide gene expression profiling by RNA Sequencing versus microarray in bronchial biopsies of COPD patients before and after inhaled corticosteroid treatment: does it provide new insights?}},
  author = {Ditz, Benedikt and Boekhoudt, Jeunard G. and Aliee, Hananeh and Theis, Fabian J. and Nawijn, Martijn and Brandsma, Corry-Anke and Hiemstra, Pieter S. and Timens, Wim and Tew, Gaik W. and Grimbaldeston, Michele A. and Neighbors, Margaret and Guryev, Victor and van den Berge, Maarten and Faiz, Alen},
  journal = {ERJ Open Research},
  publisher = {European Respiratory Society (ERS)},
  year = {2021},
  month = apr,
  doi = {10.1183/23120541.00104-2021},
  url = {https://doi.org/10.1183/23120541.00104-2021},
  pmid = {34164552},
  pmcid = {PMC8215328}
}
.bib file