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Plate IV.473 · Publications

Epigenetic germline inheritance of diet-induced obesity and insulin resistance

Article in Nature Genetics, 14 March 2016.

Diabetes, Children, Risk

  1. Peter Huypens
  2. Steffen Sass
  3. Moya Wu
  4. Daniela Dyckhoff
  5. Matthias Tschöp
  6. Fabian Theis
  7. Susan Marschall
  8. Martin Hrabě de Angelis
  9. Johannes Beckers

Abstract

There is considerable controversy regarding epigenetic inheritance in mammalian gametes. Using in vitro fertilization to ensure exclusive inheritance via the gametes, we show that a parental high-fat diet renders offspring more susceptible to developing obesity and diabetes in a sex- and parent of origin-specific mode. The epigenetic inheritance of acquired metabolic disorders may contribute to the current obesity and diabetes pandemic.

Cite

@article{huypens2016epigenetic,
  title = {{Epigenetic germline inheritance of diet-induced obesity and insulin resistance}},
  author = {Huypens, Peter and Sass, Steffen and Wu, Moya and Dyckhoff, Daniela and Tschöp, Matthias and Theis, Fabian and Marschall, Susan and de Angelis, Martin Hrabě and Beckers, Johannes},
  journal = {Nature Genetics},
  publisher = {Springer Science and Business Media LLC},
  year = {2016},
  month = mar,
  doi = {10.1038/ng.3527},
  url = {https://doi.org/10.1038/ng.3527},
  pmid = {26974008}
}
.bib file