Plate IV.4 · Publications

ArchMap is a web-based platform for reference-based analysis of single-cell datasets

Article in Nature Genetics, 30 September 2026.

Open accessResearch area: Cell Atlas, Integration

Authors

  1. Mohammad Lotfollahi
  2. Chelsea Bright
  3. Ronald Skorobogat
  4. Mohammad Moghareh Dehkordi
  5. Xavier George
  6. Simon Richter
  7. Vladimir A. Shitov
  8. Aleksandra Topalova
  9. Helena Melcher
  10. Noah Nussbaumer
  11. Annika Fomm
  12. Malte D. Luecken
  13. Fabian J. Theis

Abstract

Leveraging single-cell reference atlases to analyze new data has brought about a paradigm shift in single-cell data science akin to the first reference genome in genomics. However, methods for performing this mapping require computational expertise and, oftentimes, considerable compute power, limiting access for researchers who may benefit the most. Here ArchMap, a no-code query-to-reference mapping tool, removes this barrier by providing all-in-one automated mapping, cell-type annotation and collaborative features to analyze single-cell datasets from a wide range of integrated, often published, reference atlases and allows the extension of atlases with the growing Human Cell Atlas and related efforts. This paves the way for a democratization of reference mapping capabilities.

Versions3

  1. PublishedNature Genetics10.1038/s41588-026-02756-y
  2. PreprintResearch Square10.21203/rs.3.rs-5110946/v1
  3. PreprintbioRxiv10.1101/2024.09.19.613883

Cite

@article{lotfollahi2026archmap,
  title = {{ArchMap is a web-based platform for reference-based analysis of single-cell datasets}},
  author = {Lotfollahi, Mohammad and Bright, Chelsea and Skorobogat, Ronald and Dehkordi, Mohammad Moghareh and George, Xavier and Richter, Simon and Shitov, Vladimir A. and Topalova, Aleksandra and Melcher, Helena and Nussbaumer, Noah and Fomm, Annika and Luecken, Malte D. and Theis, Fabian J.},
  journal = {Nature Genetics},
  publisher = {Springer Science and Business Media LLC},
  year = {2026},
  month = sep,
  doi = {10.1038/s41588-026-02756-y},
  url = {https://doi.org/10.1038/s41588-026-02756-y},
  pmid = {42816602},
  pmcid = {PMC13649598}
}
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