Plate IV.358 · Publications
Altered relaxation times in MRI indicate bronchopulmonary dysplasia
Article in Thorax, 2 May 2019.
Abstract
We developed a MRI protocol using transverse (T2) and longitudinal (T1) mapping sequences to characterise lung structural changes in preterm infants with bronchopulmonary dysplasia (BPD). We prospectively enrolled 61 infants to perform 3-Tesla MRI of the lung in quiet sleep. Statistical analysis was performed using logistic Group Lasso regression and logistic regression. Increased lung T2 relaxation time and decreased lung T1 relaxation time indicated BPD yielding an area under the curve (AUC) of 0.80. Results were confirmed in an independent study cohort (AUC 0.75) and mirrored by lung function testing, indicating the high potential for MRI in future BPD diagnostics. TRIAL REGISTRATION: DRKS00004600.
Cite
@article{forster2019altered,
title = {{Altered relaxation times in MRI indicate bronchopulmonary dysplasia}},
author = {Förster, Kai and Ertl-Wagner, Birgit and Ehrhardt, Harald and Busen, Hannah and Sass, Steffen and Pomschar, Andreas and Naehrlich, Lutz and Schulze, Andreas and Flemmer, Andreas W and Hübener, Christoph and Eickelberg, Oliver and Theis, Fabian and Dietrich, Olaf and Hilgendorff, Anne},
journal = {Thorax},
publisher = {BMJ},
year = {2019},
month = may,
doi = {10.1136/thoraxjnl-2018-212384},
url = {https://doi.org/10.1136/thoraxjnl-2018-212384},
pmid = {31048507}
}