Plate IV.329 · Publications
Eleven grand challenges in single-cell data science
Review in Genome Biology, 7 February 2020.
Abstract
The recent boom in microfluidics and combinatorial indexing strategies, combined with low sequencing costs, has empowered single-cell sequencing technology. Thousands-or even millions-of cells analyzed in a single experiment amount to a data revolution in single-cell biology and pose unique data science problems. Here, we outline eleven challenges that will be central to bringing this emerging field of single-cell data science forward. For each challenge, we highlight motivating research questions, review prior work, and formulate open problems. This compendium is for established researchers, newcomers, and students alike, highlighting interesting and rewarding problems for the coming years.
Cite
@article{lahnemann2020eleven,
title = {{Eleven grand challenges in single-cell data science}},
author = {Lähnemann, David and Köster, Johannes and Szczurek, Ewa and McCarthy, Davis J. and Hicks, Stephanie C. and Robinson, Mark D. and Vallejos, Catalina A. and Campbell, Kieran R. and Beerenwinkel, Niko and Mahfouz, Ahmed and Pinello, Luca and Skums, Pavel and Stamatakis, Alexandros and Attolini, Camille Stephan-Otto and Aparicio, Samuel and Baaijens, Jasmijn and Balvert, Marleen and Barbanson, Buys de and Cappuccio, Antonio and Corleone, Giacomo and Dutilh, Bas E. and Florescu, Maria and Guryev, Victor and Holmer, Rens and Jahn, Katharina and Lobo, Thamar Jessurun and Keizer, Emma M. and Khatri, Indu and Kielbasa, Szymon M. and Korbel, Jan O. and Kozlov, Alexey M. and Kuo, Tzu-Hao and Lelieveldt, Boudewijn P.F. and Mandoiu, Ion I. and Marioni, John C. and Marschall, Tobias and Mölder, Felix and Niknejad, Amir and Rączkowska, Alicja and Reinders, Marcel and Ridder, Jeroen de and Saliba, Antoine-Emmanuel and Somarakis, Antonios and Stegle, Oliver and Theis, Fabian J. and Yang, Huan and Zelikovsky, Alex and McHardy, Alice C. and Raphael, Benjamin J. and Shah, Sohrab P. and Schönhuth, Alexander},
journal = {Genome Biology},
publisher = {Springer Science and Business Media LLC},
year = {2020},
month = feb,
doi = {10.1186/s13059-020-1926-6},
url = {https://doi.org/10.1186/s13059-020-1926-6},
pmid = {32033589},
pmcid = {PMC7007675}
}