Fabian Theis
Principal investigator
Single-cell genomics · Perturbation responses · Bulk omics and genetics
Topics · Biology and medicine · Disease areas
Metabolism and diabetes
Work on metabolism and metabolic disease, such as diabetes, obesity, pancreatic islets, adipose tissue and metabolite levels in the body. Not for metabolomics used only as a measurement for another question.
In Biology and medicine › Disease areas73 works1 person
People1
Publications73
Pregestational maternal diabetes primes neonatal beta cell dysfunction with structural remodelling, impaired calcium buffering and altered mTORC2–Gαq–PKCα signalling in a pig model
Type 2 diabetes prevention across the life course
InterScale reveals multi-scale cellular interaction programs in spatial transcriptomics
TNF alpha unmasks enteric malate aspartate shuttle dysfunction bridging Parkinson disease and intestinal inflammation
A multimodal cross-species comparison of pancreas development
Single-cell multiome and spatial profiling reveals pancreas cell type–specific gene regulatory programs of type 1 diabetes progression
GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice
Spatial profiling of human pancreas during type 1 diabetes progression
A reversible state of hypometabolism in a human cellular model of sporadic Parkinson’s disease
Delineating mouse β-cell identity during lifetime and in diabetes with a single cell atlas
Tolerance of repeated toxic injuries of murine livers is associated with steatosis and inflammation
A transcriptional cross species map of pancreatic islet cells
Synaptotagmin-13 orchestrates pancreatic endocrine cell egression and islet morphogenesis
Heterogeneous Development of β-Cell Populations in Diabetes-Resistant and -Susceptible Mice
Toward modeling metabolic state from single-cell transcriptomics
Repeated toxic injuries of murine liver are tolerated through microsteatosis and mild inflammation
Vertical sleeve gastrectomy triggers fast β-cell recovery upon overt diabetes
Künstliche Intelligenz und maschinelles Lernen in der Diabetesforschung
Diet-induced alteration of intestinal stem cell function underlies obesity and prediabetes in mice
Chronic WNT/ß-catenin signaling impairs mitochondrial function in lung epithelial cells
CD81 marks immature and dedifferentiated pancreatic β-cells
Asc-1 regulates white versus beige adipocyte fate in a subcutaneous stromal cell population
Identification and characterization of distinct brown adipocyte subtypes in C57BL/6J mice
Self-supervised retinal thickness prediction enables deep learning from unlabelled data to boost classification of diabetic retinopathy
Identification and characterization of distinct murine brown adipocyte lineages
Alterations of multiple alveolar macrophage states in chronic obstructive pulmonary disease
Targeted pharmacological therapy restores β-cell function for diabetes remission
Establishment of a high-resolution 3D modeling system for studying pancreatic epithelial cell biology in vitro
Comprehensive single cell mRNA profiling reveals a detailed roadmap for pancreatic endocrinogenesis
Dynamic modelling of an ACADS genotype in fatty acid oxidation – Application of cellular models for the analysis of common genetic variants
A map of β-cell differentiation pathways supports cell therapies for diabetes
Common patterns of gene regulation associated with Cesarean section and the development of islet autoimmunity – indications of immune cell activation
Inferring population dynamics from single-cell RNA-sequencing time series data
Impact of Brain Fatty Acid Signaling on Peripheral Insulin Action in Mice
Metabolic regulation of pluripotency and germ cell fate through α‐ketoglutarate
Maternal whole blood cell miRNA-340 is elevated in gestational diabetes and inversely regulated by glucose and insulin
pulver: an R package for parallel ultra-rapid p-value computation for linear regression interaction terms
Reconstructing cell cycle and disease progression using deep learning
Systematic single-cell analysis provides new insights into heterogeneity and plasticity of the pancreas
Prediction of type 1 diabetes using a genetic risk model in the Diabetes Autoimmunity Study in the Young
Peptide serum markers in islet autoantibody-positive children
Lactation is associated with altered metabolomic signatures in women with gestational diabetes
Epigenetic germline inheritance of diet-induced obesity and insulin resistance
Metabolomics reveals effects of maternal smoking on endogenous metabolites from lipid metabolism in cord blood of newborns
The global gene expression profile of the secondary transition during pancreatic development
Gender-specific pathway differences in the human serum metabolome
The Human Blood Metabolome-Transcriptome Interface
Effects of High-Dose Oral Insulin on Immune Responses in Children at High Risk for Type 1 Diabetes
Multi-omic signature of body weight change: results from a population-based cohort study
Metabolism gene signatures and surgical site infections in abdominal surgery
Network-Based Approach for Analyzing Intra- and Interfluid Metabolite Associations in Human Blood, Urine, and Saliva
Feature ranking of type 1 diabetes susceptibility genes improves prediction of type 1 diabetes
Hypothalamic miR-103 Protects from Hyperphagic Obesity in Mice
Novel genetic associations with serum level metabolites identified by phenotype set enrichment analyses
An atlas of genetic influences on human blood metabolites
A strategy to find gene combinations that identify children who progress rapidly to type 1 diabetes after islet autoantibody seroconversion
Metabolite profiling reveals new insights into the regulation of serum urate in humans
Effects of smoking and smoking cessation on human serum metabolite profile: results from the KORA cohort study
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations
Mining the Unknown: A Systems Approach to Metabolite Identification Combining Genetic and Metabolic Information
A strategy for combining minor genetic susceptibility genes to improve prediction of disease in type 1 diabetes
Bayesian Independent Component Analysis Recovers Pathway Signatures from Blood Metabolomics Data
Body Fat Free Mass Is Associated with the Serum Metabolite Profile in a Population-Based Study
On the hypothesis-free testing of metabolite ratios in genome-wide and metabolome-wide association studies
The dynamic range of the human metabolome revealed by challenges
Systems Biology Meets Metabolism
Discovery of Sexual Dimorphisms in Metabolic and Genetic Biomarkers
Gaussian graphical modeling reveals specific lipid correlations in glioblastoma cells
Gaussian graphical modeling reconstructs pathway reactions from high-throughput metabolomics data
Robust Stability Analysis and Design Under Consideration of Multiple Feedback Loops of the Tryptophan Regulatory Network of Escherichia coli
Cloning and Sequencing of the Genes Encoding the Periplasmic-Cytochrome B-Containing Selenate Reductase of Thauera selenatis
Two membrane anchors of Wolinella succinogenes hydrogenase and their function in fumarate and polysulfide respiration
The quinone‐reactive Ni/Fe‐hydrogenase of Wolinella succinogenes